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KRONİK GRANÜLOMATÖZ HASTALIK


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Medicine and Hematology Glossary

KRONİK GRANÜLOMATÖZ HASTALIK

(Medicine and Hematology Glossary) :
Hastalık X kromozomuna bağlı ya da otozomal resessif geçiş gösterebilir. Süperoksit anyon yapımındaki bozukluk sonucu oluşur. Süperoksit anyonların bakteri öldürme işleminde önemli rolü vardır. Çocukluk yaşlarından başlayarak tekrarlayan, bakteriyel, bazen de mantar infeksiyonları temel klinik semptomdur. Derin dokularda lokalize apseler oluşur. En sık etken ajanların başında staphylococcus aureus ve enterobakteriler gelir. Mantarlar arasında da en sık Aspergillusa rastlanır. Tanıda NBT (nitroblue tetrazolium) testinden yararlanılır. NBT suda eriyebilen sarı renkte bir tetrazolium boyasıdır. Test sırasında solunumsal patlama yaptırılan nötrofiller boyanın mavi renk almasına neden olurlar. Yeterli solunumsal patlama olamaması durumunda boya renginde değişme olmaz. KGH için patognomonik bir testtir.
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